Circulation

Circulation and Microcirculation

I have worked with experiments that investigate the circulation of cells at different levels.

At a macroscopic level, the analysing of images of dorsal skin chambers allow the visualisation of implanted tumours where the vasculature is clearly visible. This allows the analysis of vascular function and vascular shapes, and the many changes that can happen when substances are administrated.

At a microscopic level, we can focus on cells as they move through vasculature; then we can see their routes, and the velocities at which they travel, and how these change when substances enter the vessels.

Research in this area is closely related to Cancer and Cell Migration; please explore the other research pages and the publications below.

Team members:

Muhammad Moazzam Jawaid

PhD Student
Alumni, City, University of London

Collaborators:

Chryso Kanthou

School of Medicine, University of Sheffield

Greg Slabaugh

Director of the Digital Environment Research Institute, Queen Mary, University of London

Gillian Tozer

School of Medicine, University of Sheffield

Luis Martinez-Lemus

Medical Pharmacology and Physiology, University of Missouri, USA

Publications:

Morphological Analysis of Fenestrae in Arteries Muhammad Moazzam Jawaid, Francisco Ramirez-Perez, Antoine Plumerault, Flora Quilichini, Jose Alonso Solis-Lemus, Luis Martinez-Lemus, Constantino Carlos Reyes-Aldasoro Published in Emerging Technologies in Computing. First International Conference, iCETiC 2018, August 2018 (see publication) Research themes: Circulation, Image Processing Type: Conference

Automated Quantification of Non-Calcified Coronary Plaques in Cardiac CT Angiographic Imagery M. Moazzam Jawaid, Sanam Narejo, Nasrullah Pirzada, Junaid Baloch, C. C. Reyes-Aldasoro, Greg Slabaugh Published in International Journal of Advanced Computer Science and Applications (IJACSA), January 2018 (see publication) Research themes: Circulation, Medical Imaging Type: Paper

Framework for detection and localization of coronary non-calcified plaques in cardiac CTA using mean radial profiles Muhammad Moazzam Jawaid, Atif Riaz, Ronak Rajani, Constantino Carlos Reyes-Aldasoro, Greg Slabaugh Published in Computers in Biology and Medicine, October 2017 (see publication) Research themes: Circulation, Medical Imaging Type: Paper

A hybrid energy model for region based curve evolution - Application to CTA coronary segmentation Muhammad Moazzam Jawaid, Ronak Rajani, Panos Liatsis, Constantino Carlos Reyes-Aldasoro, Greg Slabaugh Published in Computer Methods and Programs in Biomedicine, June 2017 (see publication) Research themes: Circulation, Medical Imaging Type: Paper

Maternal Hyperleptinemia Is Associated with Male Offspring’s Altered Vascular Function and Structure in Mice Kathleen A. Pennington, Francisco I. Ramirez-Perez, Kelly E. Pollock, Omonseigho O. Talton, Christopher A. Foote, Constantino C. Reyes-Aldasoro, Ho-Hsiang Wu, Tieming Ji, Luis A. Martinez-Lemus, Laura C. Schulz Published in PLoS ONE, January 2016 (see publication) Research themes: Circulation Type: Paper

Arterial Stiffening in Western Diet-Fed Mice Is Associated with Increased Vascular Elastin, Transforming Growth Factor-β, and Plasma Neuraminidase Christopher A. Foote, Jorge A. Castorena-Gonzalez, Francisco I. Ramirez-Perez, Guanghong Jia, Michael A. Hill, Constantino C. Reyes-Aldasoro, James R. Sowers, Luis A. Martinez-Lemus, Published in Frontiers in Physiology, January 2016 (see publication) Research themes: Circulation, Medical Imaging Type: Paper

Regional variation in arterial stiffening and dysfunction in Western diet-induced obesity Shawn B. Bender, Jorge A. Castorena-Gonzalez, Mona Garro, Constantino C. Reyes-Aldasoro, James R. Sowers, Vincent G. DeMarco, Luis A. Martinez-Lemus Published in American Journal of Physiology. Heart and Circulatory Physiology, August 2015 (see publication) Research themes: Circulation Type: Paper

Haemodynamics and Oxygenation of the Tumour Microcirculation Gillian M. Tozer, Rachel Daniel, Sarah Jane Lunt, Constantino C. Reyes-Aldasoro, Vincent J. Cunningham Published in Advances in Intravital Microscopy, September 2014 (see publication) Research themes: Cancer, Circulation Type: Book Chapter

Online chromatic and scale-space microvessel-tracing analysis for transmitted light optical images Constantino Carlos Reyes-Aldasoro, Meit A. Björndahl, Simon Akerman, Jamila Ibrahim, Michael K. Griffiths, Gillian M. Tozer Published in Microvascular Research, November 2012 (see publication) Research themes: Cancer, Circulation Type: Paper

Microflow of fluorescently labelled red blood cells in tumours expressing single isoforms of VEGF and their response to vascular targeting agents Simon Akerman, Constantino Carlos Reyes-Aldasoro, Matthew Fisher, Katie L. Pettyjohn, Meit A. Björndahl, Helen Evans, Gillian M. Tozer Published in Medical Engineering & Physics, September 2011 (see publication) Research themes: Cancer, Cell Migration, Circulation Type: Paper

CAIMAN an online algorithm repository for Cancer Image Analysis Constantino Carlos Reyes-Aldasoro, Michael K. Griffiths, Deniz Savas, Gillian M. Tozer Published in Computer Methods and Programs in Biomedicine, August 2011 (see publication) Research themes: Cancer, Circulation, Medical Imaging Type: Paper

An automatic algorithm for the segmentation and morphological analysis of microvessels in immunostained histological tumour sections C. C. Reyes-Aldasoro, L. J. Williams, S. Akerman, C. Kanthou, G. M. Tozer Published in Journal of Microscopy, June 2011 (see publication) Research themes: Cancer, Circulation Type: Paper

Application of intravital microscopy in studies of tumor microcirculation Sarah Jane Lunt, Colin Gray, Constantino Carlos Reyes-Aldasoro, Stephen J. Matcher, Gillian M. Tozer Published in Journal of Biomedical Optics, February 2010 (see publication) Research themes: Cancer, Cell Migration, Circulation Type: Paper

Blood vessel maturation and response to vascular-disrupting therapy in single vascular endothelial growth factor-A isoform-producing tumors Gillian M. Tozer, Akerman, Simon and Cross, Neil A. and Barber, Paul R. and Björndahl, Meit A. and Greco, Olga and Harris, Sheila and Hill, Sally A. and Honess, Davina J. and Ireson, Christopher R. and Pettyjohn, Katie L. and Prise, Vivien E. and Reyes-Aldasoro, Constantino C. and Ruhrberg, Christiana and Shima, David T, Chryso Kanthou Published in Cancer Research, April 2008 (see publication) Research themes: Cancer, Circulation Type: Paper

Measuring the velocity of fluorescently labelled red blood cells with a keyhole tracking algorithm C. C. Reyes-Aldasoro, G. M. Tozer Published in Journal of Microscopy, January 2008 (see publication) Research themes: Cancer, Circulation Type: Paper

Estimation of apparent tumor vascular permeability from multiphoton fluorescence microscopic images of P22 rat sarcomas in vivo Constantino Carlos Reyes-Aldasoro, Ian Wilson, Vivien E. Prise, Paul R. Barber, M. Ameer-Beg, Borivoj Vojnovic, Vincent J. Cunningham, Gillian M. Tozer Published in Microcirculation, January 2008 (see publication) Research themes: Cancer, Cell Migration, Circulation Type: Paper