Circulation

Circulation and Microcirculation

I have worked with experiments that investigate the circulation of cells at different levels.

At a macroscopic level, the analysing of images of dorsal skin chambers allow the visualisation of implanted tumours where the vasculature is clearly visible. This allows the analysis of vascular function and vascular shapes, and the many changes that can happen when substances are administrated.

At a microscopic level, we can focus on cells as they move through vasculature; then we can see their routes, and the velocities at which they travel, and how these change when substances enter the vessels.

Research in this area is closely related to Cancer and Cell Migration; please explore the other research pages and the publications below.





Team members:

Collaborators:

Greg Slabaugh

Director of the Digital Environment Research Institute, Queen Mary, University of London

Publications:

Morphological Analysis of Fenestrae in Arteries
Muhammad Moazzam Jawaid, Francisco Ramirez-Perez, Antoine Plumerault, Flora Quilichini, Jose Alonso Solis-Lemus, Luis Martinez-Lemus, Constantino Carlos Reyes-Aldasoro
Published in Emerging Technologies in Computing. First International Conference, iCETiC 2018, August 2018 (see publication)
Research themes: Circulation, Image Processing
Type: Conference
Maternal Hyperleptinemia Is Associated with Male Offspring’s Altered Vascular Function and Structure in Mice
Kathleen A. Pennington, Francisco I. Ramirez-Perez, Kelly E. Pollock, Omonseigho O. Talton, Christopher A. Foote, Constantino C. Reyes-Aldasoro, Ho-Hsiang Wu, Tieming Ji, Luis A. Martinez-Lemus, Laura C. Schulz
Published in PLoS ONE, January 2016 (see publication)
Research themes: Circulation
Type: Paper
Arterial Stiffening in Western Diet-Fed Mice Is Associated with Increased Vascular Elastin, Transforming Growth Factor-β, and Plasma Neuraminidase
Christopher A. Foote, Jorge A. Castorena-Gonzalez, Francisco I. Ramirez-Perez, Guanghong Jia, Michael A. Hill, Constantino C. Reyes-Aldasoro, James R. Sowers, Luis A. Martinez-Lemus,
Published in Frontiers in Physiology, January 2016 (see publication)
Research themes: Circulation, Medical Imaging
Type: Paper
Microflow of fluorescently labelled red blood cells in tumours expressing single isoforms of VEGF and their response to vascular targeting agents
Simon Akerman, Constantino Carlos Reyes-Aldasoro, Matthew Fisher, Katie L. Pettyjohn, Meit A. Björndahl, Helen Evans, Gillian M. Tozer
Published in Medical Engineering & Physics, September 2011 (see publication)
Research themes: Cancer, Cell Migration, Circulation
Type: Paper
Blood vessel maturation and response to vascular-disrupting therapy in single vascular endothelial growth factor-A isoform-producing tumors
Gillian M. Tozer, Akerman, Simon and Cross, Neil A. and Barber, Paul R. and Björndahl, Meit A. and Greco, Olga and Harris, Sheila and Hill, Sally A. and Honess, Davina J. and Ireson, Christopher R. and Pettyjohn, Katie L. and Prise, Vivien E. and Reyes-Aldasoro, Constantino C. and Ruhrberg, Christiana and Shima, David T, Chryso Kanthou
Published in Cancer Research, April 2008 (see publication)
Research themes: Cancer, Circulation
Type: Paper
Estimation of apparent tumor vascular permeability from multiphoton fluorescence microscopic images of P22 rat sarcomas in vivo
Constantino Carlos Reyes-Aldasoro, Ian Wilson, Vivien E. Prise, Paul R. Barber, M. Ameer-Beg, Borivoj Vojnovic, Vincent J. Cunningham, Gillian M. Tozer
Published in Microcirculation, January 2008 (see publication)
Research themes: Cancer, Cell Migration, Circulation
Type: Paper